Why Get Your “Glutathione Antioxidant Fix” at Replenish 360 with Your Intravenous (IV) Hydration Therapy and Wellness Services?
Why Get Your “Glutathione Antioxidant Fix” at Replenish 360 with Your Intravenous (IV) Hydration Therapy and Wellness Services?
Authored by Ryan Lagazon Nuqui, MD
Peer Reviewed by Aaron Noah Smith, MD
Updated: September 14, 2018; Published: September 14, 2018
What is Glutathione Antioxidant?
First of all, let’s talk about Glutathione’s chemical make-up before we delve into its antioxidant properties and its many health benefits. It is a polypeptide made up of three proteins, mainly glycine, cysteine, and glutamic acid. This tri-peptide macromolecule is, arguably, by far one of the most important and superior antioxidant in the human body that is essentially found in every single cell and tissue in your body since it also genuinely helps, supports and considerably counteracts free radicals, which have a negative impact on your overall health in general by preventing cellular death that may cause unwanted health effects such as acceleration and further progression of the aging process. From an organic chemistry perspective, a free radical is an uncharged molecule that is only short-lived usually and is very highly reactive due to an unpaired valence electron, which fundamentally causes cataclysmic havoc in the body in simple layman’s terms. These undesirable free radicals (mostly originating from one’s own reactive metabolism in cellular respiration and physiologic reactions and processes that aid in releasing your body’s waste products, particularly during exposures to toxins, radiation and toxic metals) are not only very reactive but they may cause superfluous cellular and molecular damage and modification whenever they mix with the healthy parts of your body.
Thus, Glutathione may be one of the most crucial antioxidant in trying to eliminate surplus free radicals from your body after being exposed to the very detrimental consequences of every day radiation, chemicals, and environmental pollutants in our ever-constant search for better overall health and wellness as well as “Going Green” by pursuing knowledge and practices that can lead to more environmentally friendly and ecologically responsible decisions and lifestyles. Our body’s intricate networks of defenses try to neutralize these potentially harmful free radicals through complicated metabolic and physiologic stabilizing processes – but our daily intake of essential vitamins, supportive minerals, and particular other encouraging macromolecules and compounds such as Glutathione may help alleviate and reverse the detrimental cellular and molecular processes and damaging effects of free radicals that may lead to, as emphasized previously, cellular and molecular impairment and hastening of the aging process.
There are actually two types of molecular forms of this principal antioxidant, Glutathione (GSH) and Glutathione Disulfide (GSSG), which the former converts to its oxidized form and also called L-(-)-Glutathione. More about the two types later on possibly (e.g., GSSG topical cream formulations or by mouth with the over-the-counter oxidized form of L-Glutathione supplemental pills are what your would usually see on the open market in the health and drug stores) but essentially Glutathione protects your every cell in your body or at least it tries to and then breaks down into free Glutamate. Glutathione is actually inside all of your cells – meaning it is intracellular and endogenous – and has an exceptional knack to boost and augment the activity of all of the other vital antioxidants, including Vitamin C and E, CoQ10, and alpha lipoic acid, which can be found in all of your colorful and vibrant fruits and vegetables that you can most certainly sensibly incorporate in your every day diet without even resorting to any sort of other supplementations.
What is more interesting is that the main purpose of Glutathione which makes it, debatably, the “Master Antioxidant” is because of not only what we have stated above as far as its health and wellness benefits in scavenging unsolicited free radicals but it does additionally protect your healthy cells – exclusively, it justly guards one important double-layered organelle in your cells, the mitochondria, found in the majority of your cells where the biochemical process of cellular respiration and energy production occurs through its folded inward layers of cristae. Energy deficiency through low coenzymes in the body, specifically adenosine triphosphate (ATP), which is a complex biological chemical that participates in many cellular, metabolic, and physiologic processes but most importantly in energy production, goes hand-in-hand with low Glutathione levels. Thus, this makes Glutathione a very essential factor in your energy production, detoxification, and may even be purportedly and perhaps one of the few healthy solutions to prevent the progression of diseases associated with aging(such as age-related diseases that of Alzheimer’s and Parkinson’s Disease), coronary artery and peripheral vascular diseases, autoimmune diseases, inflammatory conditions (such as rheumatoid arthritis and myalgia), and as well as some benign and malignant cancers in some cases. However, regardless of any of these supposed health and wellness benefits and its properties as the “Master Antioxidant,” it is thus wise and smart to follow the lifestyle recommendations and guidelines of your licensed medical professionals, such as your primary care physicians (PCPs), and other healthcare specialists, such as capable and seasoned cardiologists, immunologists, allergist, rheumatologists, hematologists, oncologists, neurologists, psychiatrists, and other allopathic, osteopathic, and naturopathic healthcare experts – to appropriately prevent, treat, and manage any disease processes and medical issues that may cause debilitation, disability and decreased quality of life and expectancy.
How can I naturally increase my intake of Glutathione, the “Master Antioxidant,” through my regular diet?
Since Glutathione is a naturally occurring tri-peptide macromolecule protein, you can intuitively increase your dietary Glutathione intake naturally and, thus, energetically gain and profit from its purported health and wellness benefits, innately, through the many organic whole foods and fresh produce (that free from risky hormones and preservatives) that may contain significant amounts of Glutathione or its precursors. Simply put, if you eat a “healthy diet” in a delicate and balanced way, you can naturally have Glutathione’s antioxidant properties and its health and wellness benefits at your side.
This Is Why Eating Healthy Is Hard (Time Travel Dietician)
The best way to get your antioxidants is actually by having a well rounded and balanced diet that contains a variety of nourishing foods containing Glutathione or its precursors, which are specifically foods that are very rich in sulfur-containing amino acids. In general though, there is not one miracle lifestyle change, drug or supplement that can instantly positively transform your body into optimizing and promoting health and wellness because it is, obviously, multi-factorial in nature consisting of not only a proper balanced and individualized nutritious diet (with or without a dietician following your progress) but also additionally daily or consistent moderate physical activity for weight control, augmented endorphins and its benefits of prevention of metabolic syndrome and decreasing the risk of numerous and countless co-morbidities; following your primary care physicians and specialists’ recommendations on your specific health and wellness concerns or medical and clinical problems; and, most importantly, adopting healthy, mature and intuitive coping skills to counteract life’s psychosocial challenges in addition to having a constant positive and uplifting outlook in your goals for health and wellness for not only you but, most vitally, your special loved ones and friends that make all of the difference in the world by being by your side – at all times – as your most trusted and significant social support system in your life, especially.
Remember, a “well-rounded and balanced diet” objectively and perhaps arguably consist of hydrating regularly with electrolytes and eating frequently throughout the day with portion control comprising of your major food groups in colorful and fresh fruits and vegetables that have vital sources of vitamins, minerals, fiber, and phytonutrients for a healthy metabolism; carbohydrate-based meals in starchy and whole grain foods for energy maintenance such as potatoes, wheat bread, brown rice, and pasta for instance; nutritious protein sources for growth and repair such as vegetable-based beans and other pulses proteins (e.g., peas, chickpeas, and lentils), seafood (e.g., fish), poultry and eggs, unprocessed red meat products, dairy or dairy alternatives in fat-free or reduced fat milk and probiotic rich yogurt), and nuts and seeds for your daily intake of amino acids; and frugal polyunsaturated and generous monounsaturated fatty acids in “Mediterranean diet” oils and spreads (i.e., monounsaturated fats are in olive oils, peanut oils, canola oils, avocados, and most nuts while polyunsaturated fats are essentials fats such as corn oils, sunflower oils, and safflower oils) to reduce harmful LDL cholesterol (“bad cholesterol), lowers triglycerides, and improve your cholesterol profile by increasing HDL cholesterol (“good cholesterol”) as well as needed for blood clotting and muscle movement and reduction of destructive inflammation.
With that said, which specific and exclusive types of nourishments should you subscribe and buy into in order to naturally have Glutathione frequently in your diet? Well, to get your “Glutathione Antioxidant Fix,” you can astutely consume wholesome fresh produce and vegetables (since over cooked veggies becomes denatured in some aspects and may have reduced and even negligible macro-, micro-, and phyto-nutrient contents thereafter) in your vegetarian-based regimen such as in squash, okra, garlic, asparagus, cauliflower, broccoli, and spinach; nourishing Glutathione-rich fruits like wholesome tomatoes and avocados; smart protein and amino acid sources of foods in your carnivorous-based diet include the highest levels of Glutathione in fresh, fresh and unprocessed and organic meats and raw milk products (absent almost entirely in pasteurized dairy products), and poultry foods in eggs; other non-carnivorous and vegetarian-based protein sources in tree nuts like cashews, walnuts and almonds (by the way, peanuts come from the ground and not considered tree nuts); and supplementary healthy sources of hearty carbohydrates which may include squash and potatoes. To promote health, wellness and longevity in general, however, one should always wisely stick to fresh and whole food based nutritional products that are definitely rich in these specific food groups to naturally increase your Glutathione levels for its antioxidant and health and wellness benefits.
Yet, what’s more alarming, the “typical cliché of the Western American diet” (as opposed to the conventional and perhaps more nourishing “Mediterranean diet” and “Asian diet”) – which may possibly be promoting the increased in population weight gain, national obesity epidemic, metabolic syndrome, debilitating and uncontrolled diabetes mellitus, detrimental cardiovascular diseases, and other seemingly countless disparaging co-morbidities – may not always include the aforementioned beneficial and nutritious foods containing Glutathione that maybe another keen motive of yours to possibly consider supplementing and complementing your diet with this “Super-Food” and “Master Antioxidant” in the first place.
Well-rounded and Balanced Diet
As a side note though regarding the national obesity epidemic and obesity rate in the United States (U.S.) are the following epidemiologic statistics: 34.3% young adults ages 20-39 from 2011 to 2014 are considered obese, 41% of middle-aged adults have the highest obesity rate in this age group of 40-59 from 2011 to 2014, 38.5% of seniors ages 60 and older are affected with obesity too, and 19% of children 1 years old to puberty are sadly also obese. Go figure!
How does regular physical activity and moderate exercise increase my Glutathione levels inherently?
Based on the scholarly abstract and study by Elokda AS and Nielsen DH entitled the “Effects of exercise training on Glutathione Antioxidant System,” the so-called Glutathione Antioxidant System in the human body has been methodically supported to play a significant role in the maintenance and conservation of good health as well as the prevention of acute and chronic disease process – which is, moreover, another reason why so many people are trying to delve into enhancing their Glutathione levels and its precursors naturally not only through a well balanced and healthful diet but also through regular physical activity and moderate exercise without even resorting to other professed nutritional supplementations and marketed prescribed administration of Glutathione.
Consistent physical activity and moderate exercise (e.g., mainly aerobic exercise training, circuit weight training, and combined aerobic exercise with circuit weight training) is actually a very easy and doable favorable habit of increasing your Glutathione levels in your body. The abstract and study investigated the effects of these multiple modes of exercise training on the Glutathione Antioxidant System and found all of the cohort experimental groups having significant pre- and post-training upsurges in the resting Glutathione Antioxidant System. It was one of the first studies to accomplish a prospective longitudinal investigation involving multiple modes of exercise training illustrating a positive relationship and cumulative effects on the Glutathione Antioxidant System, which may potentially have encouraging clinical implications to not only healthy persons but also for ill individuals who need cardiac and pulmonary rehabilitation per the report. This is just one of the major healthful drives and motivation for why regular, daily or even just weekly aerobic and weight training workouts are extremely and tremendously valuable and integral for your overall health and wellness goals.
Universally speaking, the benefits of regular physical activity and moderate exercise are innumerable and virtually limitless: controlling your weight loss and maintenance goals by keeping your body mass index (BMI) under control which preferably should be between the target ranges 18.5 to 24.9; remedying, alleviating, and preventing, inherently, obesity and metabolic syndrome associated with modifiable risk factors in hypertension, hyperlipidemia, diabetes mellitus type 2, and other conditions accompanying a sedentary lifestyle and weight gain; combating numerous acute and chronic health ailments and diseases associated with old age and destructive regimen that plagues every nation in the world, including decreasing the incidence and prevalence of cardiovascular diseases such as debilitating myocardial infarctions (MIs) or “heart attacks,” cerebrovascular accidents (CVAs) or “strokes,” malignant overgrowths in cancer, chronic lower respiratory disease, Alzheimer’s disease and moderate to severe dementia, type 1 and type 2 diabetes mellitus, influenza virus infection and community acquired pneumonia, and acute and chronic renal disease just to name a few; alleviating inflammation, myalgia, and arthralgia as well as increased energy, reduced fatigue, reduced anxiety and depression, and improvement in sleep quality in autoimmune disease such as rheumatoid arthritis (RA), osteoarthritis (OA) and fibromyalgia; help prevent the progression of osteopenia, osteoporosis, geriatric falls, and pelvic and long-bone fractures by strengthening bone structure and mass to yield a confident dual-energy x-ray absorptiometry (DEXA) scan or “bone density scan;” increasing your baseline energy and vigor by improving your perfusion of blood flow and, thus, nutrients and oxygen delivery to your cells and tissues while augmenting your muscle tone, strength and boosting of your endurance throughout the day; improvement of your overall mood and disposition to provide you with the confidence, emotional lift, and self-esteem to especially counteract the psychosocial stressors of your life and challenging activities of daily living (ADLs) and may even be a healthy and mature method to channel your addiction and craving for cigarette smoking, detrimental gambling, other use of illicit drugs, and mental health and behavioral health issues harming your fitness and holistic well being, for example; heightening sleep promoting effects without the use of over-the-counter sedatives and addicting scheduled drugs by diminishing sleep latency and increasing sleep duration for your ideal sleep range of 7 – 9 hours for adults ages 26 to 64 years of age; preserving, advancing and improving your physical and aesthetic appearance and figure, which may organically and naturally enhance your libido in both men and women (e.g., specially for those men who have erectile dysfunction as an alternative to phosphodiesterase inhibitors in your brand name Viagra® – Slidenafil Citrate – and Cialis® – Tadalafil) to put a valuable catalyst in your healthy sex and love life with your significant other and partner; and, more notably, even passively offering you the added benefit of a strong and communal social interactions, relationships and associations through constructive, enjoyable engagement of regular physical activity and any form of exercise with your closest family, relatives, friends, peers, and other social circles.
As a side note, Medical News Today’s Newsletter promoted the “The Top 10 Leading Causes of Death in the United States” on February of 2017.
Epidemiologically and bio-statistically speaking, what’s interesting is that these ten causes of death attributed to about a three quarters of all deaths in the United States (U.S.) with the top three causing more than 50% of all the mortality in the U.S.
Based the Center of Disease Control (CDC) in 2014 stated a staggering age-adjusted death rate of 823.7 deaths per 100,000 U.S. standard populations with 2,626,418 deaths registered in the U.S. The life expectancy at birth is about 78.8 years old.
Not surprisingly, heart disease is the most common cause of death in the U.S., accounting for about 25% of the deaths with men being more affected than women, who may have atypical symptoms of life-threatening heart disease, acute coronary syndrome and cerebrovascular accident.
1: Heart disease
Age-adjusted rate: 167.0
Percentage of total deaths: 23.4 percent
Age-adjusted rate: 161.2
Percentage of total deaths: 22.5 percent
3: Chronic lower respiratory disease
Age-adjusted rate: 40.5
Percentage of total deaths: 5.6 percent
Age-adjusted rate: 40.5
Percentage of total deaths: 5.2 percent
Age-adjusted rate: 36.5
Percentage of total deaths: 5.1 percent
6: Alzheimer’s disease
Age-adjusted rate: 25.4
Percentage of total deaths: 3.6 percent
Age-adjusted rate: 20.9
Percentage of total deaths: 2.9 percent
8: Influenza and pneumonia
Age-adjusted rate: 15.1
Percentage of total deaths: 2.1 percent
9: Kidney disease
Age-adjusted rate: 13.2
Percentage of total deaths: 1.8 percent
Age-adjusted rate: 13
Percentage of total deaths: 1.6 percent
Since Glutathione is a tri-peptide made of amino acids, can I take over the counter Whey and Casein protein supplements such as those you would use for workouts and exercise to increase my Glutathione antioxidant?
Speaking of vitamins and supplements, you can essentially get your tri-peptide Glutathione Antioxidant Fix naturally too by your added dietary intake of complementary amino acids in the form of the macronutrients and polypeptides of whey and/or casein protein if you can’t feed yourself the right way with well-balanced micro- and macro-nutrients.
One can enhance their diet with the fast absorbing “whey protein” and/or the slow absorbing “casein protein” to get your recommended daily dose of arguably “one of the body’s most powerful master antioxidant,” Glutathione. Both have their advantages as protein sources with high bioavailability, high-quality and rich sources of branched-chain amino acids (BCAAs) for muscle maintenance, development and restoration similar maybe almost similar to the benefits of naturally protein sources such in egg protein and a mother’s breast milk for babies. The former in egg protein is a source of power, strength, and energy as studied extensively showing eggs being used as the standard of comparison for measuring protein quality in that their essential amino acid (EAAA) content and profile and high digestibility are chief importance for its popularity for its contribution to the synthesis and maintenance of muscle and indirectly to the regulation of blood glucose levels and other metabolic functions, which may also play a role in the Glutathione Antioxidant System. The latter in the mother’s breast milk or neonatal, infant, or children’s formula (i.e., these protein bases are usually derived from that of cow’s milk protein and alternatively sometimes originating from soy) are another example of high quality protein that are critical to human life and normal physiological.
However, the distinguishable difference between the two sources of high-quality and high-bioavailability proteins is their behavior during the gastrointestinal (GI) digestive process, specifically in regards to the acidity of the stomach from the gastric acid composed of hydrochloric acid (HCl) and potassium chloride (KCl), and sodium chloride (NaCl).
On one hand, whey proteins are fast-absorbing and ideally best taken especially within 45-minutes during post-workouts because whey proteins remain in aqueous solution (i.e., in liquid form) and the absorption rate in the small intestinal duodenum, jejunum, and ileum (where most of your oral absorption into your body comes from) is quicker than that of the slow-absorbing casein proteins. On the other hand, casein protein is especially useful during evening meals as it is slowly released and absorbed by your GI tract and, thus, you gain constant amino acid sources (as an anti-catabolic or muscle-spearing agent) even while you are sleeping (e.g., as a side note, as you go through your active dream-like low-amplitude, high-frequency waves and alpha rhythm in your rapid-eye-movement (REM) where neurological motor function is mostly disabled as well as your slower and more synchronized high-amplitude and low-frequency waves and K spindles of N1, N2, and N3 deepest stages of non-REM sleep cycles at night, as one would observe in diagnostic sleep studies on electroencephalogram (EEGs) to restore our bodies and minds).
Nevertheless, since casein protein usually is considered more allergenic and a culprit of a multitude of milk allergies due to its “reactive” slow-absorbing nature and whey protein is usually digested within 20-30 minutes after oral intake and absorbed quickly into the blood stream – to be utilized effectively by your tissues and cells not only for effective rapid protein synthesis as well as help keep oxidative damage at bay via it’s antioxidant promoting advantages – the best choice maybe a mixture of both or just simply whey protein when in doubt. The next question you may ask is which whey protein to purchase and use for your overall health and Glutathione Antioxidant supplement?
Obviously, you would want to wisely stray from added unwanted chemicals and substances within these whey protein supplements by reading the labels, researching the type of brand and manufacturer to support your supplementary goals of increased Glutathione Antioxidant naturally and safely. If you’re going to choose a whey protein, please always make sure it originates from grass-fed cows that have not been exposed to their food with harmful insecticides or pesticides (with organophosphates and other unhealthy substances) and injected with anabolic steroidal hormones that may lead to untraceable or apparent dysfunction in your physiologic and metabolic processes and feedback hormonal activity; only cold processed whey protein should be chosen as too much heat may possibly denature the fragile polypeptide molecular structures of the whey protein and decreased its effectiveness; whey protein is usually in better form and purchased as hydrolyzed form (pre-digested, purest, quickest absorption, most bio-available, easily digested and then absorbed and, thus, the most expensive) or even isolate (processed for purity, very digestible and absorbed, and also moderately expensive) rather than concentrate (one of the least processed form and it’s probably the cheapest since it is has added ingredients such as the bloating-causing lactose) whey protein; preferably low in your macronutrient carbohydrates and sweetened naturally as opposed to artificial sugared in some supplementary products; and majority of the time has more medium chain fatty acids as compared to long chain fatty acids which are not as digestible as the former.
Can you take oral daily supplements with Glutathione pills to reap its benefits?
Although you are always welcome to take by mouth (i.e., PO) Glutathione supplements as over the counter (OTC) pills in powder, capsule and tablet forms, the absorption rate from your digestive tract in these types of formulations and oral administration have been shown to be relatively poor compared to non-enteral administration in general. It’s even worse if you have some type of malabsorption syndrome, metabolic issues, renal and liver disease that might prevent appropriate absorption of macro- and micronutrients.
Some corroborated reports have suggested, though, to maybe sensibly supplement with an oral dose daily dose of 250 mg of reduced L-Glutathione that is a over-the-counter (OTC) that you can easily purchase in your local health and wellness shops and stores. Obviously, one can bolster intuitively his or her Glutathione levels even more by including glutathione-rich foods through a well-balanced diet as continuingly insinuated, which can be combined with still other supplemental OTC Glutathione precursors like n-acetyl-cysteine, selenium, and alpha lipoic acid. For some experts, recommendation and consensus – based on current studies or lack there of – would be more practical if one takes these precursors of Glutathione since your body can use these foundations of the precursors for your body to make more of your own “master antioxidant.”
Moreover, since most substantiated studies show that oral Glutathione supplements have been proven to show poor absorption in the GI tract versus other non-enteral administration and, ironically, may actually interfere with your body’s own Glutathione production (by negative feedback inhibition halting your body’s own production of this crucial antioxidant), supplementing with just oral Glutathione pills may not be your answer to magnifying your Glutathione levels to its daily physiologic potential of scavenging free radicals even though all of us are actually capable of producing our own free radical scavengers and defenses through our body’s inherent Glutathione and other antioxidants, such as Superoxide Dismutase (SOD) enzymes.
In addition, there are also other herbal remedies, such as milk thistle and curcumin, that some have proposed are an excellent foundation of increasing your Glutathione by preventing antioxidant depletion in the liver.
However, there are some instances that may potentially decrease Glutathione’s favorable effects for detoxification: any form of liver disease whether mild, moderate, or severe; excessive intake of acetaminophen (i.e., brand name of Tylenol); unwarranted alcohol (ETOH) consumption that may increase liver damage as seen in elevated liver function tests (LFTs); viral infection in acute or chronic hepatitis that may also systematically affect all parts of your body and not just the Glutathione Antioxidant System.
In the end though, it may be a lot wiser to just always have a wholesome diet and general recommendations for your specific health care needs. One must not rely exclusively on any one regimen or suggestion to meet all of your daily requirements of Glutathione Antioxidant as this may set up potential disappointments. As in anything with life, meeting all of your health and wellness goals may be multifactorial in nature.
What are the additional rewards, benefits and advantages of Glutathione Antioxidant supplementation, especially through Replenish 360’s Exclusive IV Hydration Therapy and Wellness Services?
Remember, daily or regular Glutathione intake fulfillment through a well-balanced diet filled with whole foods and fresh produce along with supplementary amino acids in whey and/or casein protein powders and OTC Glutathione (and its main precursors such as n-acetyl-cysteine, selenium, and alpha lipoic acid) tablets or capsules are more than enough to meet your “master antioxidant” goals for your health, wellness, and fitness. However, Replenish 360 IV Hydration Therapy offers your Glutathione Antioxidant intravenously (IV) has a much more quicker, effective, superior and enhanced absorption rate and uptake in your tissues and cells than sparingly and frugally taking Glutathione by mouth (PO), whether that from your diet or OTC supplements, because of the fact that it literally is administered safely intravascularly directly through your veins and bloodstream (i.e., intravenously and parenteral). What are the additional rewards, benefits and advantages of intravenous (IV) Glutathione at Replenish 360?
For one, a few selected celebrities and figures, avid health enthusiasts, or other persons craving for a much lighter skin tone and color have marketed and promoted the Glutathione for not only its antioxidant properties but also for its skin-lightening and “whitening” effect as an off-label topically administered GSSG cream formulations or taken orally with the OTC reduced form of L-Glutathione supplemental tablets or capsules. The former off-label topically administered GSSG cream formulation’s effectiveness in the skin-lightening outcome are thoroughly explained in the study by Watanabe et al.
The Authors Watanabe et al published in 2014 regarding Glutathione formulations with topical (GSSG cream) with a randomized, double-blinded, placebo-controlled, matched-paired study. The study subject included 20 healthy Filipino women aged 30-50 years with baseline facial melanin index value of 200-350. The methodology used included a 2% (w/w) GSSG cream lotion and placebo lotion that were randomly assigned to either the right or the left side of the face of each subject and was spread evenly to the designated site twice daily for about 10 weeks in duration. The parameters were evaluated objectively with the frequency of evaluation at baseline and then weekly for 10 weeks: One parameter included skin lightening (over cheek bones) – by Mexameter® MX18 and other parameters included skin moisture, skin smoothening, wrinkles and skin firmness. The tolerance and safety was very well tolerated, with no untoward symptoms reported. There was only one subject with an adverse effect of erythema of the entire face on Day 1 of the study that subsided in 2 days without stopping the use of either lotion (GSSG cream and placebo lotion). The limitations on the study was the small sample size of 30 health Filipino women and the short duration of the study, which was only 10 weeks and there was no follow-up results obtained after the study was completed (i.e., the follow-up results were not mentioned beyond the study duration of 10 weeks). In addition, the study may not extrapolate for other ethnic groups. Nevertheless, the results for skin lightening showed progressive and significant reduction in melanin index values over 10 weeks at the GSSG cream application sites as compared to the placebo sites. The other results demonstrated suggested that significantly higher skin moisture for GSSG sites than placebo sites in Weeks 8 and 9 of the study; significantly lower curvature index values at GSSG sites than placebo sites in Weeks 6 and 10 of the study; significantly lower Keratin index values at GSSG sites than at placebo sites from Weeks 6 to 10 of the study; and no significant difference between the two sites regarding the elasticity index values.
Glutathione orally, however, used as an antioxidant has a standard dosage for oral intake (dependent on the person’s body weight) is usually doubled in dosage if it is used as a skin-whitening agent. Obviously, the latter’s duration of treatment depends on the individuals desired skin color and a maintenance dose is ideal afterwards. The skin melanin index is being modified and manipulated to actually “whiten” the skin systemically, which may be used for cosmetic reasons or for more appropriate use of possibly reversing facial hyperpigmentation that may perhaps be the a culprit for age spots.
Evidence of Glutathione as a skin lightening agent through oral capsules is presented in a 2010 publication by the Authors Arjinpathana and Asawanonda whose study design was randomized, double-blinded, and placebo controlled. The study subjects included 60 healthy medical students aged 19-22 years old who were block-randomized to receive either Glutathione (500 mg) or placebo capsules daily, in two divided doses on an empty stomach for 4 weeks. The parameters evaluated objectively at the baseline and at the end of the study (4 weeks) were the melanin index, standardized digital photographs. The parameter of melanin index by Mexameter® was measured in triplicate at about six sites grouped in sun-exposed areas (face in the left and right sides and extensor surfaces of the forearms in the left and right sides). The parameter of standardized digital photographs was quantitatively evaluated for Ultraviolet (UV) spots, pores, and evenness on the left and right sides of the face. The study groups tolerated the treatment very well and the only adverse effects were flatulence from one subject in the Glutathione group during the initial days and constipation reported by one of the other subjects receiving the placebo group. However, again the follow-up results were not obtained beyond the 4 weeks of study duration and length (i.e., follow-up for evaluation of persistence of efficacy is lacking). Some limitations in the study included its short study period of 4 weeks and a small sample size of 60 healthy medical students.
There was another study by the Authors Handog et al published in 2015 that displayed an open-labeled, single-arm pilot study for oral lozenges for buccal mucosal absorption of Glutathione, which studied a group of 30 healthy women (aged 22 to 24 years of age) with Fitzpatrick skin types IV or V, with melanin indices of more than 20 (maximum value = 99). The methodology described the cohort group using one lozenge (500 mg) per day that was kept in the mouth against the inner cheek (buccal mucosa) and clinical evaluation was performed at baseline and every two weeks over a periods of eight weeks by a portable Mexameter. The parameters evaluated include the Melanin index (by Mexameter) and measurements were done in triplicate and the mean was taken at two sites: Sun-exposed areas such as the extensor surface of the right wrist and sun-protected area in the mid-sternum. The results showed that the melanin index in all subjects (100%) receiving Glutathione at both sun-exposed and sun-protected sites had significant reduction in melanin index (p < 0.0001). The Global Assessment demonstrated twenty-seven of the subjects (90%) noted moderate skin lightening and three noted mild skin lightening (10%). The treatment group in those who completed the study tolerated the Glutathione oral lozenges very well. There were no adverse effects amongst those who completed the study but one drop out complained of soreness of gums due to the lozenges. Some limitations on the study included no follow-up investigations beyond the 8-week duration of the study. Follow-up for evaluation of persistence of efficacy is lacking. It was also a very short study period of 8-weeks with only 30 subjects on a small sample size that comprised of healthy young adults.
Along with its antioxidant and skin-lightening and whitening properties, Glutathione may play a role in cosmetic and aesthetic improvement through supplementation, especially in the IV form at Replenish 360. Fascinatingly, there have been particular rising investigations and explorations, which illustrate Glutathione’s utilization in cosmetic and aesthetics. Specifically, as opposed to other cosmetic and aesthetic methods to increase dermal skin turnover rate, heighten the appearance of more volume and manipulate neuromuscular physiology to reduce wrinkles and other signs of photo-aging (e.g., with other cosmetic and aesthetic procedures in facial deep cleansing, chemical glycolic acid peels, Botulinum toxin and dermal filler injections, and in addition to more invasive dermatological procedures such as rhinoplasty and “face lifts,” for instance, by your qualified and specialized dermatologists and plastic surgeons), there are several interesting readings and analyses that showed marked improvement in the number and severity of wrinkles as well as enhanced dermal perfusion with continued use of Glutathione supplementation. However, these studies were seen more for oral supplementary intake of Glutathione.
Yet, the most promising way Glutathione may perhaps help you in your health and wellness goals – other than its antioxidant properties – is its prominent anti-aging properties. For instance, some animal and laboratory studies concluded and determined the potential of Glutathione to aid in combating a multitude of age-related diseases, specifically those that are associated with free radicals that lead to diseases of “old age,” which includes cardiovascular associated diseases in coronary artery and peripheral vascular diseases, heart attacks and strokes from obesity and uncontrolled or untreated hypertension, hyperlipidemia, diabetes mellitus; prominent age-related diseases like chronic and debilitating Parkinson’s Disease and Alzheimer’s Disease; some autoimmune diseases and inflammatory conditions such as rheumatoid arthritis and fibromyalgia; particular benign tumors and malignant cancers; and event other medical illnesses remarkably related to age-related diseases such as cataracts and male infertility, to some extent. The reason being is that Glutathione is a very essential factor in your energy production and detoxification, which is perhaps the chief reason for its purported use in preventing the progression of diseases, associated with the inevitable aging population of the United States.
What’s more promising regarding Glutathione’s proposed health and wellness benefits are also some interesting evidence as suggested through select randomized double-blinded controlled studies that have shown a positive relationship of Glutathione taken intravenously (IV) specifically for those who were being treated with chemotherapy for cancer (e.g., ovarian cancer), for instance. The outcome of the findings and analyses basically hinted that – compared to the control placebo group – the cohort group who had IV Glutathione while on chemotherapy agents for their ovarian cancer had decreased and fewer side effects and adverse reactions as well as had better overall survival rates in general. Despite these promising evidenced-based conclusions about Glutathione, it should also be sensibly noted that expert consultation with a licensed board certified hematologist and oncologist and other competent medical specialists working together and cohesively for a common goal of remission and prevention of tumor growth and proliferation are obviously needed in order to properly treat and manage suspicious benign tumors and any malignant cancers, for that matter.
What does Replenish 360 recommend as far as IV Hydration Therapy, Wellness Services and Glutathione Antioxidant? When and how many times can I get supplemental IV Hydration Therapy with Glutathione Antioxidant?
Although wisely reaping the encouraging rewards of Glutathione for its antioxidant properties and other significant health and wellness benefits from your dietary and nutritional intake through naturally eating fresh produce, taking supplementary amino acids in whey and casein protein shakes, moderately exercising with aerobic and anaerobic activities or enhancing daily Glutathione or its pre-cursors through complementary OTC pills, it can be shrewdly deduced and inferred that there are no hard and solid evidence that the former and latter may work perfectly and ideally for every single individual since it is multifactorial and everyone’s lifestyle, daily habits, and makeup is different and diverse in nature genetically, metabolically, and physiologically. However, there is a growing and emerging consensus that Glutathione is indeed not as well absorbed into the body when taken and administered enterally by mouth or orally (PO) as compared to non-enteric administration intravenously (IV) as you would absolutely receive safely and expertly your “Glutathione Antioxidant Fix” with Replenish 360’s IV Hydration Therapy and Wellness Services.
Our brilliant licensed and certified healthcare practitioners – Registered Nurses (RNs) and Paramedics (EMT-P) who are competently experienced and qualified intravenous (IV) therapists and medics with thorough knowledge of our Standing Order and Procedures (SOPs) – can provide you with a safe, preventative and healthy dose of your IV Hydration Therapy with your “Glutathione Antioxidant Fix” in a prepared sterile aseptic wellness capacity in our first-rate and exceptional offices and concierge services using standard of care techniques and equipment appropriate and unique for your individualized health, wellness and fitness goals. You treatment can be infused with other assortments of revitalizing and nourishing electrolytes, amino acids and other micro- or macronutrients for your overall hydration needs as well as options for our other vital and beneficial vitamins for more of a vibrant energy, heightened immune support, sharper focus and demeanor, and better sleep in combination with as needed remedies for your gnawing indigestion, mild nausea, and pain from your sore muscles that may accompany signs and symptoms of mild dehydration or volume depletion.
What are the contraindications, side effects, and adverse reactions of your IV Hydration Therapy and Wellness Services with Glutathione Antioxidant Treatments at Replenish 360?
Although Glutathione Antioxidant through IV Therapy infusions is appropriately kindly to your general health, wellness and fitness goals when administered safely and with concurrent standards of care by Replenish 360’s competent and well-trained medical and wellness staff, there are always some side effects, adverse reactions, and contraindications to any form of well recommended, proposed and prescribed treatments, therapies and remedies whether it is non-invasive, holistic and wellness in nature, for that matter, as is the cases for even over-the-counter herbal supplements, medications, and drugs approved by the Federal Food and Drug Administration (FDA) to be distributed and consumed in the open market.
As a prime example, for instance, even the most commonly and widely used drug in the world, caffeine, in higher and unrestrained doses has unwelcoming secondary aftereffects such as in amplified sympathetic nervous system stimulation or the “fight or flight” response: high heart rate or “tachycardia,” high blood pressure or “hypertension;” palpitations, “diaphoresis” or sweating, tremors, and altered mentation as presentations sometimes placed in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) of Caffeine Use Disorder diagnoses causing anxiety, panic attacks, insomnia (if caffeine is consumed later in the day) and other not otherwise specified (NOS) caffeine-related disorders; gastrointestinal (GI) or digestive issues due its laxative effects from increased peristalsis and gastrin hormone production as well as urinary or “micturition” issues in polyuria and urinary urgency and frequency; catabolic muscle breakdown due to gluconeogenesis from the generation of glucose from non-carbohydrate substrates such as glycogenic amino acids; and rebound fatigue or the “caffeine crash” after serum caffeine levels significantly drops after a couple of hours of the initial dose of caffeine administration, which are just to name a few side effects of this world-wide drug.
With that stated and in relation to Glutathione, prevention and preparation is, again, paramount and superior to handling and doctoring the possible actual aftermath and response of rare but conceivable small risks, side effects and adverse reactions while receiving IV Therapy infusions with Glutathione Antioxidant at Replenish 360.
Because every individual’s immunological make-up is diverse and distinctive, what is beneficial for one may not be the same for another. Although Glutathione Antioxidant through Replenish’s 360 IV Hydration Therapy in the recommended standard of care doses is rather and fairly safe, every medication and treatment may have possible contraindications, side effects and adverse reactions dependent on one’s immune and metabolic responses – such as those very rare instances for an individual with a true and severe life-threatening allergy that may cause not only rashes but also internal and external angioedema through an anaphylactic reaction to the components of any treatment or therapy for that matter that may need immediate medical emergency management and attention of the emergency medical response system (EMS) to be transported to the emergency department (ED) to clinically reverse serious signs and symptoms of cardiopulmonary compromise with intramuscular (IM) epinephrine auto-injectors or intravenous epinephrine, antihistamine with diphenhydramine or Benadryl brand name, famotidine or Pepcid brand name, and other anti-inflammatory treatments in nebulized and steroid therapies, if available. Based on some studies and as with any prescribed or OTC medications, there may be a minute chance of also adverse cutaneous eruptions ranging from skin rashes, to serious and potentially fatal Stevens Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) that have been reported as side effects and adverse effects to Glutathione.
Specifically, Glutathione and probably its pre-cursors and derivatives should also be cautiously avoided in individuals who have sulfa derivative and medication allergies that include common antibiotic combination drugs (i.e., trimethoprim-sulfamethoxazole in Septra and Bactrim brand names) and erythromycin-sulfisoxazole; sulfasalazine (i.e., Azulfidine brand name) for autoimmune diseases like Crohn’s disease, Ulcerative Colitis (UC), and Rheumatoid Arthritis (RA); and Dapsone medications used for Dermatitis, specific forms of Pneumonia, and even Leprosy.
In addition and as stated overall, receiving IV Hydration Therapy with Glutathione Antioxidant or its precursors at Replenish 360 in reasonable amounts appears to be quite safe, but it should also be avoided in certain susceptible people with milk protein allergies (whey and mainly casein polypeptide derivatives) and in those who are already moderately to severely immunocompromised such as those who have recently received an organ transplant and on immunosuppressants and perhaps other active autoimmune deficiency syndrome (AIDS).
Those with reactive airway diseases (e.g., small airway bronchiolitis and asthma) also will need to have caution when using Glutathione Antioxidant as it may exacerbate an underlying lower airway obstruction in asthma or small airway bronchiolitis and, especially, those who have moderate to severe asthma needing not only rescue inhalers and as needed and in-home nebulized therapy but also requiring more chronic management through their primary care doctor and specialists such as their respective pulmonologists and allergists/immunologists.
More importantly, any pregnant, lactating, and women of child-bearing age who think they may be pregnant in the first few weeks of their first trimester or are already in their second and third trimesters are not recommended in receiving Glutathione because there maybe teratogenic effects in the embryo and fetus even if the studies may eventually show Teratogenic Category C class or lower Categories of D and X for Glutathione. (Category C: Either studies in animal have revealed adverse effects on the fetus that is either teratogenic or embryocidal, or other and there are no controlled studies in women or studies in women and animals are not available; drugs should be given only if the potential benefit justifies the potential risk of the fetus.) Current consensus by experts in Glutathione IV Hydration Therapy indicate that they actually do not know if taking Glutathione is safe during pregnancy and while breastfeeding. It’s always, always, always safe to assume and conclude that pre-partum, intra-partum, and post-partum periods of your pregnancy should be prudently followed by expert consultation by a qualified and licensed healthcare professional – that being obstetricians and gynecologists and/or reproductive endocrinologists among other medical professionals who are able to follow the progression of your fertility, pregnancy, and lactation including your need for dietary and supplementary needs of macro- and micro-nutrients.
Moreover, there maybe other understated adverse reactions and side effects of Glutathione Antioxidant through IV Hydration Therapy which may even include anxiety and panic attacks in those with pre-existing and concurrent behavioral health issues and any spectrum of psychiatric disorders diagnosed as generalized anxiety disorder (GAD), depression, bipolar disorder, schizophrenia, schizoaffective disorder, and other mental illnesses stated in Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5).
In general though, there are also some few and common complications of universal peripheral intravenous (IV) therapy insertions that may include vasovagal reactions or “fainting spells” (which the patient experiences vasospasms and collapsing of the vein from anxiety or the pain of the needle puncturing their soft tissues during venipuncture in addition to the signs and symptoms of turning pale, diaphoretic, nauseated, and possibly vomiting); vein irritation by the patient’s report of pain at the site of peripheral IV insertion, possible blanching, “erythema” or red skin over the vein during infusion, and perhaps quickly developing into signs of phlebitis due to the infused IV therapy solutions with high or low pH and high osmolarity (such as those mixed with possible micronutrients in the form of amino acids or polypeptides like Glutathione Antioxidant, potassium chloride (KCl), phenytoin, vancomycin, erythromycin, and nafcillin for instance); venous spasmbefalls not only due to severe vein irritation as stated in the latter but also due to the administration of cold fluids or blood, and a very rapid flow rate of the IV in which the patient will experience pain at the IV site, the flow rate of the IV will become sluggish and very slow even if the roller clamp is wide open, and the skin will be blanched over the vein; phlebitis is the inflammation of a vein that may or may not be associated with clot formation (e.g., thrombophlebitis) and other signs and symptoms of redness, swelling, pain, and edema at the peripheral IV insertion site and/or along the vein (often caused by poor perfusion around the venipuncture device, friction from catheter movement in the vein, and clotting at the catheter tip; occlusion ensues when IV fluid or medication cannot enter the vein and the IV therapy flow is disturbed and blood may be backed up in the tubing or heparin or saline lock; and hematomas and infiltration transpire when fluid or blood leaks into the extravascular space and the patient will have uncomfortable tenderness at the site, a bruise may be evident at the IV insertion site, and the IV therapy infusion will not flow at all or at a slower rate.
Nevertheless, there are relatedly sometimes very unusual and certainly infrequent complications of peripheral intravenous (IV) therapy insertions even with standard of care techniques utilized by a competent and seasoned IV operator or medic that may include not only anaphylactic reactions, reactive airway diseases, teratogenicity, and anxiety but also thrombosis may occasionally happen when the platelets cling to the tunica intima of the vein due to vessel injury during venipuncture with the designated vein appearing painful, red and swollen in addition to a sluggish IV infusate flow rate; extravasation inappropriately happens rarely when the venipuncture device is dislodged from the vein with signs and symptoms of swelling at and above the limb, discomfort, burning or pain at the site, tightness at the site, cooler temperature at the site, blanching at the site, and absent backflow of blood; catheter dislodgementunluckily arises when the catheter backs out of the vein and the IV therapy solution may infiltrate, the catheter will be backed out further than normal from the vein and the tape may be loose; nerve, tendon or ligament damageinopportunely follows due to improper venipuncture technique, tight taping or improper arm board application with the patient experiencing tremendous pain at the insertion site, numbness, muscle contraction and finally may display paralysis, numbness and deformity; circulatory overloadcan unfortunately strike when the IV therapy roller clamp is loosened and the infusate is allowed to run into the vein quickly, especially in patients with moderate to severe heart failure, renal disease, or liver disease which may cause the patient to be more anxious, experience respiratory distress and shortness of breath (e.g. dyspnea), crackles in the lung bases upon auscultation (e.g., interstitial lung disease with flash pulmonary edema), increased blood pressure (e.g., increased intravascular volume) and neck engorgement (e.g., increased jugular venous distention due to fluid overload); air embolismmay seldom and rarely occur when the IV therapy solution container runs empty and the added container pushes enough significant air down the line into the patient causing the patient to experience respiratory distress and shortness of breath (e.g. dyspnea), unequal breath sounds upon auscultation, a weak and thready pulse, increased central venous pressure, decreased blood pressure (e.g., hypotension due to an obstructive shock case), and loss of consciousness or altered mentation; and local cellulitis, systemic infection or bacteremia can infrequently transpire as a result of phlebitis, poor taping that allows the venipuncture device to move in and out of the vein, prolonged dwell time of the catheter, and failure to maintain aseptic technique during IV insertion or site care and many hours later the patient may experience malaise, fever, and chills which may turn into critical sepsis.
The IV operator or medic may also have an increased risk for needle-stick accidents or injuriesthat are caused by needles that accidentally puncture the skin and can occur at any time when the IV therapy equipment is utilized, disassembled, or disposed of inaptly. The IV hydration therapy patient may also need to use the restroom during the treatment and may have fall risksif the IV lines, poles, and other IV therapy equipment are not properly and safely collected and positioned.
In a very small number of patients receiving Glutathione in some studies, specifically, there were reported adverse reactions and side effects with thyroid dysfunction, kidney and liver dysfunction (with the potential of development of renal and liver failure due to the high doses administered), and even severe abdominal pain and other gastrointestinal signs and symptoms.
In the end, it is perhaps prudent and best that you have individualized and specialized screening measures and expert consultation before your intravenous (IV) therapy infusions with Glutathione Antioxidant if you have any of the following adverse reactions, side effects, and contraindications especially if you have elevated vasovagal symptoms such as being scared of needles; have a sulfa and milk protein allergies that may cause severe anaphylactic reactions; immunocompromised in severe diabetic, oncology, and HIV/AIDS patients; asthmatic with modest to stark reactive airway disease, and other severe pulmonary ailments; thyroid, heart, kidney and liver disease, dysfunction and heart failure; you think you may be pregnant, are currently pregnant or breastfeeding; and, last but not least, have an anxiety disorder and periods of panic attacks. However, rest assured that our Replenish 360’s Medical and Wellness Team have prepared safety precautions and responses in our Standard Order and Procedures (SOPs) to prevent and treat any form of medical emergencies with prevention in mind at all times. While any intravenous (IV) hydration therapy may have these adverse reactions and side effects, our excellent, skilled and capable staff are astutely cognizant, prepared, and well-trained for your safety and well-being to deal with possible medical predicaments arising from any of your treatment or therapy.
In summary, what does Replenish 360’s Glutathione Antioxidant Beauty Blend and IV Hydration Therapy all mean for your Health, Wellness and Fitness Goals?
As punctually and markedly stated and investigated, Glutathione is very interesting, to say the least, and arguably the “Master Antioxidant” found in every cell of our bodies that plays an integral role similar to other vital antioxidants like Vitamin C and E; it is vitally important for keeping our cellular health in check by favorably neutralizing free radicals, which can build up and accumulate in your cells and tissues and cause molecular and cellular functional impairment, damage and mutations. Replenish 360’s Glutathione Antioxidant Beauty Blend and IV Hydration Therapy can potentiate free radical scavenging within your cells and tissues for the goal of potentially widespread health benefits, including boosting your cells of the immune system whose job it is to fight age-related diseases. Production of Glutathione in the body may halt or be lessened due to seemingly older and advanced age in conjunction with a sedentary and unhealthy lifestyle that may not be deliberate in nature (e.g., without healthy consistent physical exercise and also poor diet and nutrition free of fresh fruits, vegetables, and unprepared meats) and there should be a nourishing and safe alternative to increasing your Glutathione Antioxidant in your cells and tissue. Choosing Replenish 360’s Glutathione Antioxidant Beauty Blend and IV Hydration Therapy may be one of the keys to your success in your overall health, wellness and fitness goals.
Want an effective hydration remedy to get your “master antioxidant,” skin glowing and healthy? Well, try our new-revamped Antioxidant Beauty Blendthat is a 500 ml IV skin rejuvenating therapy (25-30 min. infusion) with Glutathione Antioxidant. $195.
Our full-sized Antioxidant Beauty Blend that is a 1000 ml IV drip (45-60 min infusion) with Glutathione Antioxidant is also available for you to choose from for your hydration and wellness needs. $255.
Want pre-cursors to Glutathione Antioxidant, muscle recovery and increased muscle mass? Try our new-revamped Muscle Mass Hydration, which includes our Signature Hydration 500 ml IV Therapy (25-30 min. infusion) with analgesic pain remedy and then sip on a whey and casein protein shake with branched-chain amino acids (BCAA) to keep your muscle pumps and decrease soreness from the weekend’s activities. $190.
Our full-sized Muscle Mass Hydration that is a 1000 ml IV drip (45-60 min infusion) with analgesic pain remedy in addition to a supplementary whey and casein protein shake with branched-chain amino acids (BCAA) is also available for you to choose from for your hydration and wellness needs. $250.
If you have anymore questions or concerns, please feel free to leave us your contact information below and write us a message and we will get back to you as soon as we can for your IV Hydration Therapy and Wellness Program!
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