Vitamin C (Ascorbic Acid) Benefits and

IV Hydration Therapy at Replenish 360

Authored by Ryan Lagazon Nuqui, MD

Peer Reviewed by Aaron Noah Smith, MD

Updated: January 4, 2020; Published: December 26, 2019

What are the advantages and rewards of Replenish 360’s IV Hydration Therapy focused on Wellness and Preventative intravenous (IV) or intramuscular (IM) services with Vitamin C or Ascorbic Acid?

Vitamin C (Ascorbic Acid) is a major water-soluble antioxidant that is present in fruit and vegetables in the diet and offers many functions in maintaining optimum health and fitness. It is an essential micronutrient for humans due to its pleiotropic functions or ability to donate electrons that create a very potent antioxidant and a cofactor for a family of biosynthetic and gene regulatory enzymes.

Recent scientific evidence indicates that an increased intake of Vitamin C is associated with a reduced risk of chronic diseases such as cancer, cardiovascular disease, and cataract, probably through antioxidant mechanisms.

Recently, the Dietary Reference Intake Panel of the Institute of Medicine recommended a Vitamin C dietary allowance of 90 mg/d for men and 75 mg/d for women.

High Benefits of Vitamin C:

Vitamin C Deficiency (Scurvy) Treatment
- From the Vitamin C Deficiency (Scurvy) editorial by Luke Maxfield and Jonathan S. Crane, Scurvy is a medical syndrome that results from Vitamin C Deficiency. Accounts from pirates and British sailors made the disease infamous and ill famed. This disease was first reported in 1550 BC when people accurately labeled the diagnosis and treatment using onions and vegetables. Hippocrates formally coined the disease “ileos ematitis” with the description, “the mouth feels bad; the gums are detached from the teeth; blood runs from the nostrils… ulcerations on the legs; some of these heal… skin is thin.” In the 1700s, James Lind of the British Royal Navy determined the ingesting of lemons and oranges led to remission of the disease, and in 1927, the structure of ascorbic factor was published, with the synthesis of ascorbic acid named Vitamin C not long after.
- Vitamin C Deficiency results in fatigue and lethargy, early symptoms of Scurvy.
- Taking supplemental Vitamin C prevents, treats and reverses Vitamin C Deficiency, including Scurvy.
Support Immune Cell Functioning
- Enhanced immune defense is one of the most popular benefits of Vitamin C as it supports various cellular functions of both the innate and adaptive immune system.
- It combats a multitude of infections that supports epithelial barrier function against pathogens and promotes the oxidant scavenging activity of the skin, which feasibly protect against environmental oxidative stress.
- Bacterial, viral, and other pathogenic infections may be less likely to occur and/or may decrease the duration of the illness because Vitamin C accumulates in phagocytic cells, such as neutrophils, and can heighten chemotaxis, phagocytosis, generation of reactive oxygen species, and eventually microbial killing; it is required for apoptosis and clearance of the spent neutrophils from the infection sites by macrophages that decreases potential tissue damage; and it enhances differentiation and proliferation of B- and T-cells in lymphocytes.
- Supplementation with Vitamin C seems to prevent respiratory and systemic infections in a wide range of studies by helping combat increased inflammatory response and metabolic demands.
Reduction in Inflammation
- Having healthy effects, Vitamin C could work as an anti-inflammatory agent through its antioxidant capacity.
- The authors showed that plasma Vitamin C correlates inversely with biomarkers of inflammation such as CRP more than does dietary Vitamin C.
- Vitamin C (600 mg twice daily) has potential effects in alleviating inflammatory status by reducing hs-CRP, IL-6 and FBG in hypertensive and/or diabetic obese patients.
Collagen Production and Wound Healing through Antioxidant Effects
- Vitamin C is well known for its protein and collagen synthesis benefits for increased wound healing, such as those with decubitus ulcers, burn patients, and other ailments requiring a boost in soft tissue restorative treatments.
- Preclinical studies demonstrated that Vitamin C has the potential to accelerate bone healing after a fracture, increase type I collagen synthesis, and reduce oxidative stress parameters.
- Since normal skin contains high concentrations of Vitamin C, the supplementation of Vitamin C may support important and well-known functions, stimulating collagen synthesis and assisting in antioxidant protection against UV-induced photodamage.
Increases Blood Flow by Augmenting Nitric Oxide (NO) Production
- Ascorbic acid has been shown to stimulate endothelial nitric oxide (NO) synthesis in a time and concentration dependent fashion.
- Vitamin C is an effective scavenger of nitrite, reducing it to nitric oxide.
- Restoration of endothelial function in Heart Disease patients may possibly be another value of Vitamin C, which may improve overall vascular blood flow in atherosclerosis.
- By this same token, Vitamin C supplementation may also improve erectile dysfunction and essential hypertension by increasing vasodilation and perfusion, thereby, improving male sexual dysfunction and lowering blood pressure for better hypertension control.

Other Likely Benefits of Vitamin C:

Neurology:
- Complex Regional Pain Syndrome Prevention
  - Taking Vitamin C after surgery or injury to the arm or leg seems to prevent Complex Regional Pain Syndrome, which limb pain that usually occurs after an injury from developing.
- Pain Relief After Surgery
  - Taking Vitamin C by mouth or as an injection into the vein (by IV) one hour before or within 30 minutes of the start of anesthesia appears to decrease pain and the need for opioid pain relievers after surgery in some patients.
Ophthalmology:
- Slow Progression of Age-related Macular Degeneration (AMD)
  - Taking Vitamin C, Vitamin E, Beta-Carotene, and Zinc helps prevent AMD from becoming worse in people at high risk for developing advanced AMD. It’s too soon to know if the combination helps people at lower risk for developing advanced AMD. Also, it’s too soon to known if Vitamin C helps prevents AMD.
  - However, there have been studies that show that supplementation with Vitamin C can slow the progression of cataract and macular degeneration, an age-related eye disorder characterized by vision loss, has been a studied benefit of the supplement.
Respiratory:
- Thwarting of Upper Airway Infections (URIs) Caused by Heavy and Intense Exercise
  - Using Vitamin C before heavy physical exercise, such as a marathon, might prevent upper airway infections that can occur after heavy exercise.
Cardiovascular:
- Help Fight High Cholesterol (e.g., Hyperlipidemia)
  - Based on the UpToDate®’s Patient Education: High Cholesterol and Lipids (Beyond the Basics): High levels of lipids (fats) in the blood, including cholesterol and triglycerides, is also called “hyperlipidemia.” Hyperlipidemia can significantly increase a person’s risk of heart attacks, strokes, and other serious problems. To lower these risks, doctors often recommend that people with hyperlipidemia try to lower their cholesterol levels through a combination of dietary changes, exercise, and medication. Most cholesterol-lowering therapies are aimed at reducing low-density lipoprotein (LDL) or “bad” cholesterol. High levels of LDL can cause atherosclerosis (buildup of fatty deposits in the blood vessels), which is the major cause of cardiovascular events (heart attacks, strokes, and lower extremity or peripheral artery disease).
  - Improved cholesterol metabolism may aid in the fight against heart disease due to its antioxidant properties to reduce oxidative stress.
  - Taking Vitamin C might reduce low-density lipoprotein (LDL or “bad”) cholesterol in people with high cholesterol.
- Help Fight High Blood Pressure (e.g., Hypertension)
  - Its mild diuretic effect promotes a utility to high blood pressure.
  - Taking Vitamin C along with medicine to lower blood pressure helps lower systolic blood pressure (the top number in a blood pressure reading) by a small amount. It does not seem to lower diastolic pressure (the bottom number). Taking vitamin C does not seem to lower blood pressure when taken without medicine to lower blood pressure.
- Counter Irregular Heartbeat (e.g., Atrial Fibrillation or AFib)
  - Taking Vitamin C before and for a few days after heart surgery helps prevent irregular heartbeat after heart surgery.
- Curtail Reduced Benefit of Nitrate Therapy (e.g., Nitrate Tolerance)
  - An interesting phenomenon called Nitrate Tolerance happens when nitrates are used all day for long periods of time and ultimately results in reduced benefit of Nitrate Therapy. Basically, in some people who take medicines for chest pain, the body may develop tolerance in some patient population and these medicines have reduced benefit and may eventually stop working all together unfortunately.
  - Taking Vitamin C seems to help these medicines, such as nitroglycerine, work for longer in duration and efficacy for anginal chest pain whether Stable Angina (Angina Pectoris), Variant (Prinzmetal) Angina, Microvascular Angina, or Unstable Angina.
Gastrointestinal (GI):
- Aids in Emptying the Colon Before a Colonoscopy
  - Before a person undergoes a colonoscopy, the person must make sure that their colon is empty. This emptying is called bowel preparation. Some bowel preparation involves drinking 4 liters of medicated fluid.
  - If Vitamin C is included in the medicated fluid, the person only needs to drink 2 liters. This makes people more likely to follow through with the emptying procedure. Also fewer side effects occur. A specific medicated fluid containing Vitamin C (MoviPrep, Salix Pharmaceuticals, Inc.) has been approved by the U.S. Food and Drug Administration (FDA) for bowel preparation.
- Decrease Swelling (Inflammation) of the Stomach (e.g., Gastritis)
  - From the ACG Clinical Guideline: Treatment of Helicobacter Pylori Infection in the American Journal of Gastroenterology, Helicobacter Pylori (H. pylori) infection is a common worldwide infection that is an important cause of peptic ulcer disease and gastric cancer. H. pylori may also have a role in uninvestigated and functional dyspepsia, ulcer risk in patients taking low-dose aspirin or starting therapy with a non-steroidal anti-inflammatory medication, unexplained iron deficiency anemia, and idiopathic thrombocytopenic purpura.
  - While choosing a treatment regimen for H. pylori, patients should be asked about previous antibiotic exposure and this information should be incorporated into the decision-making process.
  - For first-line treatment, clarithromycin triple therapy should be confined to patients with no previous history of macrolide exposure who reside in areas where clarithromycin resistance amongst H. pyloriisolates is known to be low. Most patients will be better served by first-line treatment with bismuth quadruple therapy or concomitant therapy consisting of a PPI, clarithromycin, amoxicillin, and metronidazole.
    - When first-line therapy fails, a salvage regimen should avoid antibiotics that were previously used. If a patient received a first-line treatment containing clarithromycin, bismuth quadruple therapy or levofloxacin salvage regimens are the preferred treatment options. If a patient received first-line bismuth quadruple therapy, clarithromycin or levofloxacin-containing salvage regimens are the preferred treatment options. Details regarding the drugs, doses and durations of the recommended and suggested first-line and salvage regimens can be found in the guideline.
  - On occasion, medicines used to treat H. pylori infection can worsen stomach inflammation and taking Vitamin C along with one of these proton pump inhibitors (PPIs), such as omeprazole, might decrease this side effect.
Renal:
- Reduce Protein in the Urine (e.g., Albuminuria)
  - According to the study called the “Effects of Supplementation with Vitamin C or E on albuminuria, glomerular TGF-beta, and glomerular size in diabetes,” the following support the potential utility of antioxidant treatment for the prevention of renal injury in diabetes:
    - Treatment with Vitamin C, but not Vitamin E, significantly reduced kidney weight compared with that in untreated diabetic rats. Immunohistochemical staining for TGF-beta was 2.5-fold higher in glomeruli of cortical sections from untreated diabetic rats versus control rats.
    - Treatment with Vitamin C or E prevented the increase in glomerular TGF-beta immunoreactivity. Glomerular volume was also significantly increased (twofold) in kidneys of untreated diabetic rats compared with control rats, as assessed by light microscopy.
    - Treatment with Vitamin C prevented and treatment with Vitamin E reduced the increase in glomerular volume.
    - Treatment with Vitamin C also prevented the sevenfold increase in albumin clearance otherwise seen in untreated diabetic rats.
  - Therefore, taking Vitamin C plus Vitamin E can or may reduce excessive protein loss (i.e., albumin) in the urine in people with diabetes who have acute or chronic renal disease in some studies.
Rheumatology:
- Lower Risk or Prevention of Gout in Men
  - Several metabolic studies and a recent double-blinded placebo-controlled randomized trial have shown that higher Vitamin C intake significantly reduces serum uric acid levels.
    - However, the relation with the risk of Gout is unknown.
    - It should also be noted that Vitamin C alone does not treat Gout, in general.
  - However, higher Vitamin C intake from the diet seems to be independently associated and linked to a lower risk of Gout in men, specifically. It is also intriguing that supplemental Vitamin C intake may be beneficial in the prevention of Gout.
Hematology:
- Mitigate Iron Deficiency Anemia and Hemolytic Anemia
  - Vitamin C plays an important role in iron metabolism and application for red blood cell (RBC) formation.
    - Among patients with chronic kidney disease (CKD), there is association between anemia and increased chance of mortality mainly because of cardiovascular diseases and stroke, risk of hospitalization, and death prevalence in predialysis patients.
    - Infusion of ascorbate supplementation can reduce oxidative stress among hemodialysis patients, which particular studies are aimed to assess the effect of Vitamin C on patients with continuous ambulatory peritoneal dialysis (CAPD).
    - Taking Vitamin C supplements might help manage hemolytic anemia in people undergoing dialysis, where the red blood cells (RBCs) are destroyed or metabolized faster than they are made (i.e., hemolysis).
  - Thus, Iron Deficiency Anemia may be lessened by Vitamin C supplementation as the infusion of ascorbate supplementation aid in reducing oxidative stress among hemodialysis patients.
- Antioxidant Status in Lead Poisoning
  - Although several animal studies suggest a protective relationship between blood lead concentrations and ascorbic acid, there are inconclusive results regarding the beneficial effect of ascorbic acid on lead concentrations in human studies.
    - Serum ascorbic acid concentrations were inversely associated with the prevalence of elevated blood lead concentrations.
    - However, there was no significant relationship between dietary ascorbic acid intake and blood lead concentrations.
    - This suggests that there may be a protective relationship between ascorbic acid and lead.
  - Supplementation of Vitamin C is beneficial to reduce the oxidative stress and to improve the antioxidant status.
    - The high blood lead level induces oxidative stress and alters the antioxidant status.
    - However, Vitamin C is helpful to reduce the lipid peroxidation and nitrite formation and enhances the erythrocytes superoxide dismutase and catalase activity.
  - Consuming Vitamin C in the diet does not seem to lower blood levels of lead but it does improve overall antioxidant status through the reduction of oxidative stress in those with suspected or diagnosed Lead Poisoning.
Oncology:
- Cancer Care and Vitamin C
  - There’s still no evidence that Vitamin C alone can cure cancer, but researchers are studying whether it might boost the effectiveness of other cancer treatments, such as chemotherapy and radiation therapy.
  - There are still no well-done, controlled clinical trials that have shown a substantial effect of vitamin C on cancer, but some studies do suggest a mild decrease in side effects of certain cancer treatments when standard therapy is combined with high-dose IV Vitamin C.
    - The anti-cancer effect of high doses of intravenous Vitamin C (high-dose vitamin C) remains controversial despite growing evidence that high-dose Vitamin C exerts anti-tumorigenic activity by increasing the amount of reactive oxygen species in cancer cells without meaningful toxicities.
  - Combining high-dose Vitamin C with conventional anti-cancer drugs can have therapeutic advantages against breast cancer cells.
  - Potential use in in adjunctive cancer care in doses up to 25 grams intravenously can be safely used to treat presumptive ascorbate deficiency based on symptoms and could favorably affect clinical parameters such as inflammation, fatigue, and quality of life.
Musculoskeletal:
- Cartilage Loss and Osteoarthritis (OA)
  - Osteoarthritis (OA) is the most prevalent joint disease. Dietary intake of vitamin C relates to a reduction in cartilage loss and OA.
    - This study examined the efficacy of vitamin C to prevent OA with the in vitro chondrosarcoma cell line (SW1353) and the in vivo monosodium iodoacetate (MIA)-induced OA rat.
    - Results demonstrated that, in SW1353 cells, treatment with 5 μM MIA inhibited cell growth and increased oxidative stress, apoptosis, and proteoglycan loss. In addition, the expression levels of the pro-inflammatory cytokines IL-6, IL-17A, and TNF-α and matrix metalloproteinases (MMPs) MMP-1, MMP-3, and MMP-13 were increased. All of these MIA-induced changes could be prevented with treatment of 100 μM vitamin C. In an animal model, intra-articular injection of MIA-induced cartilage degradation resembled the pathological changes of OA, and treatment of vitamin C could lessen these changes.
    - Unexpectedly, vitamin C’s effects did not strengthen with the increasing dosage, while the 100 mg/kg dosage was more efficient than the 200 or 300 mg/kg dosages.
  - Vitamin C possessed multiple capacities for prevention of OA progress, including a decrease in apoptosis and in the expression of pro-inflammatory cytokines and MMPs in addition to the well-known antioxidation.
  - Taking Vitamin C from dietary sources or from calcium ascorbate supplements seems to prevent cartilage loss and worsening of symptoms in people with osteoarthritis.
Skin:
- Decrease skin redness caused by injury or irritation (erythema) and wrinkled skin.
  - Using a skin cream containing Vitamin C might decrease skin redness following laser resurfacing for scar and wrinkle removal.
    - Postoperative erythema of several months duration is a universal and problematic side effect of cutaneous carbon dioxide (CO2) laser resurfacing.
    - The application of topical L-ascorbic acid in an aqueous formulation resulted in a significant decrease in post-CO2 laser resurfacing erythema by the eighth postoperative week when compared with laser-irradiated skin that had not received topical Vitamin C.
  - Taking Vitamin C seems to improve and help reduce erythema and the appearance of wrinkled skin.
- Improve Second Degree Burn
  - Taking Vitamin C alone does not prevent first, second, and third burns but may improve the sunburn.
    - In this study, participants have got an age average of 43.03 ± 11.90, 60% of participants were composed of men, and the other 40% were women.
    - The results of ANOVA Test showed repetitive measurements.
    - The average of final score of burn between two types of cures was statistically significant (P=0.047).
  - In other words, there was a significant difference on improving the burn between two groups, and Vitamin C takes a significant effect on improving the burn.
Psychiatric:
- Anxiety, Depression and Psychological Stress
  - The mechanism of lowering cortisol may reduce both the physical and psychological effects of stress on people.

Dietary Intake and Dosage:

When taken for the Daily Requirements of of Vitamin C in the absence of deficiency or disease, the recommended dietary allowance (RDA) of Vitamin C is as follows:

Recently, the Dietary Reference Intake Panel of the Institute of Medicine recommended a Vitamin C dietary allowance of 90 mg/d for men and 75 mg/d for women.
In the absence of deficiency, daily requirements are up to 45 mg per day in children, 90 mg per day for men, 75 mg per day for women, and up to 120 mg per day for women who are lactating.

When taken for the treatment and management of Vitamin C Deficiency (Scurvy), the recommended dietary allowance (RDA) of Vitamin C is as follows:

Direct replacement of Vitamin C is standard, with up to 300 mg daily for children and 500 mg to 1000 mg daily for adults.
The endpoint of replacement is one month or upon resolution of clinical sequelae.
Alternative treatment regimens for adults include one to 2 g for up to 3 days followed by 500 mg daily for a week followed by 100 mg daily for up to 3 months.
In addition to immediate supplementation, educate the patient on lifestyle modifications to ensure adequate intake, and recommend cessation of alcohol, and tobacco use.

When taken for the management of the Common Cold, the recommended dietary allowance (RDA) of Vitamin C is as follows:

Most research shows that taking 1-3 grams of Vitamin C might shorten the course of the cold by 1 to 1.5 days.
Taking vitamin C does not appear to prevent colds.

When taken for the reduction of Chronic Diseases, the recommended dietary allowance (RDA) of Vitamin C is as follows:

The totality of the reviewed data on some clinical studies suggests that an intake of 90–100 mg Vitamin C per day is required for optimum reduction of chronic disease risk in nonsmoking men and women.

When taken for the alleviation of General Inflammation, the recommended dietary allowance (RDA) of Vitamin C is as follows:

Vitamin C (600 mg twice daily) has potential effects in alleviating inflammatory status by reducing hs-CRP, IL-6 and FBG in hypertensive and/or diabetic obese patients.

When taken for its potential use in Adjunctive Cancer Care, the recommended dietary allowance (RDA) of Vitamin C is as follows:

While IVC may have a variety of possible applications, such as combating infection, treating rheumatoid arthritis, it has generated the most interest for its potential use in adjunctive cancer care.
The Riordan intravenous Vitamin C (IVC) protocol involves the slow infusion of vitamin C at doses on the order of 0.1 to 1.0 grams ascorbate per kilogram body mass (Riordan, et al., 2003).
Potential use in in adjunctive cancer care in doses up to 25 grams intravenously can be safely used to treat presumptive ascorbate deficiency based on symptoms and could favorably affect clinical parameters such as inflammation, fatigue, and quality of life.
Only after a thorough medical and clinical history in addition to a collaborative approach in medical care, please note the use and supplement of high doses of Vitamin C under the direction of your oncologist and other competent health care providers for its potential use in adjunctive cancer care.

When taken for prevention, wellness, and general health, the recommended dietary allowance (RDA) of Vitamin C is as follows:

Children 0 to 6 months: 40 milligrams per day
Children 7 to 12 months: 50 milligrams per day
Children 1 to 3 years: 15 milligrams per day
Children 4 and 8 years: 25 milligrams per day
Children 9 to 13 years: 45 milligrams per day
Females 14 to 18 years: 65 milligrams per day
Males 14 to 18 years: 75 milligrams per day
Females 19 and over: 75 milligrams per day
Males 19 and over: 90 milligrams per day
Pregnant females 14 to 18: 80 milligrams per day
Pregnant females 19 and over: 85 milligrams per day
Breastfeeding females 14 to 18: 115 milligrams per day
Breastfeeding females 19 and over: 120 milligrams per day

Notable Toxicities of Vitamin C:

Vitamin C has low toxicity and is not believed to cause serious adverse effects at moderate intakes.
However, high doses may have potential adverse effects even though it is a water-soluble vitamin that usually cannot be stored in the body.
Gastrointestinal Symptoms:
- Gastrointestinal Disturbances
  - The most common complaints are mild to moderate to severe diarrhea, nausea, mild abdominal cramps, and other gastrointestinal disturbances due to the osmotic effect of unabsorbed Vitamin C in the gastrointestinal tract.
Renal:
- Kidney Stones
  - More than 2,000 mg or 2G per day may increase risk of kidney stones.
    - High doses of Vitamin C can increase the risk of a rare condition called hyperoxaluria which promotes excretion of oxalic acid in the kidney tubules that may eventually lead to kidney stones.
  - In people who have had a kidney stone, amounts greater than 1000 mg daily greatly increase the risk of kidney stone recurrence.
- Weight Loss Surgery
  - Too much oxalate in the urine can cause problems such as kidney stones and can increase the risk of kidney failure in people with kidney disease.
    - Weight loss surgery can cause the body to absorb more oxalate from food. This can increase the amount of oxalate in the urine.
    - Vitamin C can also increase the amount of oxalate in the urine.
    - Taking large amounts vitamin C after weight loss surgery might increase the risk of having too much oxalate in the urine.
- Kidney Transplant Rejection
  - Long-term use of Vitamin C in high doses before a kidney transplant may increase the risk of transplant rejection or delay how long it takes until the transplanted kidney works.
Endocrine:
- Diabetes and Hyperglycemia
  - Vitamin C should be used with caution for any diabetic since it may raise the glucose levels in the body.
Cardiac:
- Heart Attack (Acute Coronary Syndrome, ACS)
  - Vitamin C levels are reduced during a heart attack.
    - However, low vitamin C has not been linked to an increased risk for heart attack.
  - In some studies of older women with diabetes, Vitamin C in high dosages more than 300 mg per day may increase the risk of death from heart disease.
- Angioplasty and Wound Healing
  - Avoid taking supplements containing Vitamin C or other antioxidant vitamins (beta-carotene, vitamin E) immediately before and following angioplasty without the supervision of a health care professional.
    - These vitamins seem to interfere with proper healing.
Neurovascular/Psychiatric:
- Alzheimer’s Disease and Mental Function
  - Taking Vitamin C along with Vitamin E and alpha-lipoic acid might worsen mental function in people with Alzheimer disease.
- Schizophrenia and Psychosis
  - Taking Vitamin C along with Vitamin E might worsen psychosis in some people with schizophrenia when taken with antipsychotic drugs.
Hematology/Oncology:
- Cancer
  - Cancerous cells collect high concentrations of Vitamin C.
    - Until more is known, only use high doses of Vitamin C under the direction of your oncologist and competent health care providers.
- G6PD Deficiency
  - A metabolic deficiency called “glucose-6-phosphate dehydrogenase” (G6PD) deficiency is needed to be ruled out before starting IV Hydration Therapy in Vitamin C.
  - Large amounts of Vitamin C can cause red blood cells to break (i.e., hemolysis) in people with this condition.
  - Avoid excessive amounts of Vitamin C in those with G6PD Deficiency.
- Thalassemia and Hemochromatosis
  - Blood-iron disorders, including conditions called “thalassemia” and “hemochromatosis” is needed to be ruled out before starting IV Hydration Therapy in Vitamin C.
  - Vitamin C can increase iron absorption, which might make these conditions worse.
  - Avoid large amounts of Vitamin C in those Thalassemia and Hemochromatosis.
Pregnancy:
- While it is safe to supplement with Vitamin C during pregnancy with dosages between 85 mg to 120 mg, high doses may harm to newborn.
Infants and Children:
- Vitamin C is possibly unsafe when taken by mouth in amounts higher than 400 mg daily for children 1 to 3 years, 650 mg daily for children 4 to 8 years, 1200 mg daily for children 9 to 13 years, and 1800 mg daily for adolescents 14 to 18 years.
Anaphylactic Reactions:
- As with any other supplement or drugs, mild to severe allergic reactions may occur with Vitamin C supplementation for certain individuals.
Drug Interactions:
- Birth Control Side Effects
  - It may slow excretion of estrogen from the body that can increase hormonal side effects in women taking estrogen-based contraceptives (birth control pills that contain some form of estradiol, ethinyl estradiol, or mestranol).
- Decrease Efficacy of Antipsychotic Drugs
  - The opposite is true of certain antipsychotic drugs such as Prolixin (fluphenazine) when taken together with Vitamin C since supplementation can reduce the concentration of Prolixin in the bloodstream.
- Decrease Efficacy of Chemotherapy Drugs
  - Vitamin C supplements in some studies found that certain chemotherapy drugs are less effective.
- Other Drug-Drug Interactions
  - Other medications that may interact with Vitamin C include Exjade (deferasirox), ferrous gluconate (Fergon, Ferrale, Ferate), Ferrous sulfate (FeoSol, Fer-Gen-Sol, Fer Iron), and Warfarin (Coumadin) just to name a few.
- ETOH and Tobacco
  - Avoid drinking alcohol when taking the supplements as drinking alcohol may diminish many nutrients in the body.
  - Smoking and chewing tobacco lowers vitamin C levels. Vitamin C intake in the diet should be increased in people who smoke or chew tobacco.

Although side effects and overdose of Vitamin C may happen scarcely, it’s best to let your primary care doctor or medical specialist know if you are planning to take Vitamin C supplement for regular, daily and as needed supplement to prevent and manage any potential adverse reactions. If there is suspected overdoses in Vitamin C, it is advisable to go to the nearest and local Emergency Department (ED) or call 911 as a cautionary recommendation. You can also contact the Poison Control Center at (800) 222-1222.

As a general rule, it is always wise to start with the lowest dosage as indicated for certain medical conditions and preventative measures to reap the benefits of Vitamin C through our IV Hydration Therapy and Wellness Services at Replenish 360. It’s best to cater to an individualized program and sessions, which our excellent and qualified staff and medical providers are firmly trained to enthusiastically encourage for your overall wellness and fitness goals!

Replenish 360 IV Hydration Therapy

Replenishing your mind and body, restoring you to your best self, and improving your health and everyday performance.

Replenish 360 offers one of the most affordable wellness and preventative services that are personalized and one of the most activating one-of-a-kind IV drip and infusions, vitamin and antioxidant supplementation, micronutrient therapy, and other additional supplementary wellness services to “renew your body, refresh your mind, and restore performance.”

Our popular flagship Replenish 360 Palm Desert, California office is now available at your convenience for your IV hydration therapy, vitamin supplementation, and other wellness services close by the nearby cities of Palm Springs, Cathedral City, Rancho Mirage, Indian Wells, Indio, Desert Hot Springs, Idyllwild-Pine Cove, Coachella, Bermuda Dunes, La Quinta, Sun City, Thousand Palms, Redlands, Morongo Valley, Cabazon, Banning, Beaumont, Yucaipa, San Jacinto, Hemet, Temecula, Twentynine Palms, Yucca Valley, Big Bear Lake, Joshua Tree, Salton Sea, Brawley, El Centro, Blythe, Calexico, Borrego Springs, and Anza!

Tier 1: Signature Hydration

What are some of the reasons to try our wellness, preventative and supplementary Signature Hydration?
- Parties and special occasions
  - Birthdays, weddings, Bar Mitzvahs, and other social events
  - Music and arts festivals like the infamous Coachella Festival, Stagecoach Festival, and Desert Trip Concert
- Competitive athletes
  - Pre and Post-workout hydration maintenance
  - Prevention of heat exhaustion and improve physical and mental performance
- Upper Respiratory Infection
  - Mild URI or common cold
  - Flu or other viral infections
- Traveling and Jet Lag
  - Fatigue with decreased energy levels
- Long work days
  - Dehydration from lack of oral intake of fluids and food
- Other numerous activities that may cause mild dehydration
What’s in it and what’s the cost? $
- Signature Hydration 500 ml IV Therapy (25-30 min. infusion). $99.
- Signature Hydration 1000 ml IV Therapy (45-60 min. infusion). $160.
How do I book an appointment?
- For more information, please contact us by phone, email, or just set up your appointment and session online!
  - Telephone: (760) 422-3114
  - Email: [email protected]
  - Online Registration!

Tier 2: Recovery Hydration

What are some of the reasons to try our wellness, preventative and supplementary Recovery Hydration?
- Hangover Headache and Nausea
  - Dehydration post drinking alcoholic beverages causing nausea, vomiting, headache, and fatigue
- Mild Food Poisoning
  - Mild stomach flu causing and accompanied by tummy ache, vomiting and diarrhea
- Delay Onset Muscle Soreness (DOMS)
  - Muscle ache, pain, and discomfort post workouts and sports activities
- Pre-menstrual cramps
  - Pre-menstruation related musculoskeletal pains
- Osteoarthritis (OA) and rheumatoid arthritis (RA)
  - Muscle soreness, inflammation, and other musculoskeletal pain
- Pre- and post-surgery
  - Prevention of mild dehydration from your scheduled surgery
- Other numerous activities that may cause mild dehydration
What’s in it and what’s the cost? $$
- Recovery Hydration 500 ml IV Therapy (25-30 min. infusion) with a blend of nausea, pain, or indigestion remedies. $140
- Recovery Hydration 1000 ml IV Therapy (45-60 min. infusion) with a blend of nausea, pain, or indigestion remedies. $190.
How do I book an appointment?
- For more information, please contact us by phone, email, or just set up your appointment and session online!
  - Telephone: (760) 422-3114
  - Email: [email protected]
  - Online Registration!

Tier 3: Lifeline Hydration

What are some of the reasons to try our wellness, preventative and supplementary Recovery Hydration?
- All-inclusive Hangover Cure
  - Moderate dehydration post drinking alcoholic beverages causing nausea, vomiting, headache, and fatigue
- Immune boost
  - Solution from your mild cold and flu that can hydrate you and give you the vitamins and pain relief to get you back up on your feet faster
- Detoxification and Wellness Remedy
  - Giving you hydration and vitamins as a supplement to your detox and wellness revival
- Intense exercise, training, and athletic competition
  - Your intense exercise and training as an athlete needs rejuvenation with a dose of preventative hydration, vitamins, and muscle and joint soreness
- Sleep support and stress relief
  - Supplement your lack of sleep for a restful remedy to insomnia and help combat the stresses of life
- Other numerous activities that may cause mild dehydration
What’s in it and what’s the cost? $$
- Recovery Hydration 500 ml IV Therapy (25-30 min. infusion) with vitamins and a blend of nausea, pain, or indigestion remedies. $195.
- Recovery Hydration 1000 ml IV Therapy (45-60 min. infusion) with vitamins and a blend of nausea, pain, or indigestion remedies. $260.
How do I book an appointment?
- For more information, please contact us by phone, email, or just set up your appointment and session online!
  - Telephone: (760) 422-3114
  - Email: [email protected]
  - Online Registration!

Tier 4: Personalized Hydration

What are some of the reasons to try our wellness, preventative and supplementary Personalized Hydration?
- Concierge Services
  - To get private personalized and VIP IV vitamin and wellness drips at the leisure of your own home or lodging during your precious vacation
- Wellness Services Memberships
  - For Premium and Executive Members only with personalized and VIP IV vitamin drips pre-scheduled bimonthly or weekly
- Beauty Maintenance
  - We can include vitamin and antioxidant hydration blends to keep your skin glowing and healthy
- Weight control
  - Weight loss programs can benefit from our personalized hydration to help supplement and keep you on track to keep or shed the pounds away
- Other numerous activities that may cause mild dehydration
What’s in it and what’s the cost? $$$
- Personalized Hydration 500 ml IV Therapy (25-30 min. infusion) with vitamins and a blend of nausea, pain, or indigestion remedies. $270
- Personalized Hydration 1000 ml IV Therapy (45-60 min. infusion) with vitamins and a blend of nausea, pain, or indigestion remedies. $360.
How do I book an appointment?
- For more information, please contact us by phone, email, or just set up your appointment and session online!
  - Telephone: (760) 422-3114
  - Email: [email protected]
  - Online Registration!

Tier 5: After Hours Hydration

What are some of the reasons to try our wellness, preventative and supplementary After Hours Hydration?
- Concierge Services
  - To get private personalized and VIP IV vitamin and wellness drips at the leisure of your own home or lodging during your precious vacation
- Wellness Services Memberships
  - For Premium and Executive Members only with personalized and VIP IV vitamin drips pre-scheduled bimonthly or weekly
- Beauty Maintenance
  - We can include vitamin and antioxidant hydration blends to keep your skin glowing and healthy
- Weight control
  - Weight loss programs can benefit from our personalized hydration to help supplement and keep you on track to keep or shed the pounds away
- Other numerous activities that may cause mild dehydration
What’s in it and what’s the cost? $$$
- After Hours Hydration 500 ml IV Therapy (25-30 min. infusion) with vitamins and a blend of nausea, pain, or indigestion remedies. $360.
- After Hours Hydration 1000 ml IV Therapy (45-60 min. infusion) with vitamins a blend of nausea, pain, or indigestion remedies. $450.
How do I book an appointment?
- For more information, please contact us by phone, email, or just set up your appointment and session online!
  - Telephone: (760) 422-3114
  - Email: [email protected]
  - Online Registration!

Replenish 360 IV Hydration Menu

Available Daily Infusions

In-house infusions are available only at our in-facility and off-site posts near you Year-round and Every Day, including most Holidays.

Vitamin Recharge Hydration

For more sustained hydration, energy and get the most of your Festival Season experience, vacation and good-times, try our Vitamin Recharge Hydration that is a 500 ml IV drip (25-30 min. infusion) with vitamins. $140.
Our full-sized Vitamin Recharge Hydration that is a 1000 ml IV drip (45-60 min infusion) with vitamins is also available for you to choose from for your hydration and wellness needs. $200.

Phoenix Immune Booster

Are you’re feeling like you’re getting a little sick this Festival Season? Why not have our new-revamped Phoenix Immune Booster that includes 500 ml IV drip (25-30 min. infusion) with Vitamin C. $180.
Our full-sized Phoenix Immune Booster that is a 1000 ml IV drip (45-60 min infusion) with vitamins along with Vitamin C is also available for you to choose from for your hydration and wellness needs. $240.

Antioxidant Beauty Blend

Want an effective hydration remedy to get your skin glowing and healthy while sunbathing outside the Coachella Polo Fields? Well, try our new-revamped Antioxidant Beauty Blend that is a 500 ml IV skin rejuvenating therapy (25-30 min. infusion) with Glutathione Antioxidant. $195.
Our full-sized Antioxidant Beauty Blend that is a 1000 ml IV drip (45-60 min infusion) with Glutathione Antioxidant is also available for you to choose from for your hydration and wellness needs. $255.

Cinderella Fusion Hydration

For a healthy, powerful and elegant mixture of our Antioxidant Beauty Blend and Phoenix Immune Booster, try our Cinderella Fusion Hydration that is a 500 ml IV drip (25-30 min. infusion) and potently supported with an anti-aging and skin refining cocktail of Vitamin C (Ascorbic Acid), Glutathione Antioxidant, and Alpha Lipoic Acid (ALA). $229.
Our full-sized Cinderella Fusion Hydration that is a 1000 ml IV drip (45-60 min infusion) is also available for you to choose from for your hydration and wellness needs. $290.

Special Music Festival Hydrations and Discounts

Festival Season Infusions

In-house infusions are available only at our in-facility and off-site posts near you during this Festival Season.

Weekend Lifeline Hydration

- Get the most of your Festival experience with vitamins and hangover relief of headache, nausea, and reflux. We can offer you our new-revamped Weekend Lifeline Hydration, which includes 500 ml IV hydration (25-30 min. infusion) with vitamins along with analgesic/pain, nausea, and indigestion remedy. $200.
- Our full-sized Weekend Lifeline Hydration that is a 1000 ml IV drip (45-60 min infusion) with vitamins along with analgesic/pain, nausea, and indigestion remedy is also available for you to choose from for your hydration and wellness needs. $260.

Coachella Recovery Hydration

For more sustained hydration, energy and get the most of your Festival Season experience, vacation and good-times, try our Coachella Recovery Hydration that is a 500 ml IV drip (25-30 min. infusion) with vitamins. $130.
Our full-sized Coachella Recovery Hydration that is a 1000 ml IV drip (45-60 min infusion) with vitamins is also available for you to choose from for your hydration and wellness needs. $190.

Festival Signature Hydration

To save money, you can also try our new half-size Festival Signature Hydration that is a 500 ml IV drip (25-30 min infusion) that gives you more bang for your buck in less time for an IV drip for those guests tagging along for some affordable hydrations. $99.
Of course, our full-sized Festival Signature Hydration that is a 500 ml IV drip (45-60 min infusion) is also available for you to choose from for your hydration and wellness needs. $160.

Hangover Headache Buster

Do you have a headache related to dehydration from your merriment and indulgence during Coachella and Stagecoach? Fear no more, we have your hangover headache cure with our new-revamped Hangover Headache Buster, which includes 500 ml IV hydration (25-30 min. infusion) with analgesic pain remedy. $175
Our full-sized Hangover Headache Buster that is a 1000 ml IV drip (45-60 min infusion) with analgesic pain remedy is also available for you to choose from for your hydration and wellness needs. $235.

Phoenix Immune Booster

Are you’re feeling like you’re getting a little sick this Festival Season? Why not have our new-revamped Phoenix Immune Booster that includes 500 ml IV drip (25-30 min. infusion) with Vitamin C. $180.
Our full-sized Phoenix Immune Booster that is a 1000 ml IV drip (45-60 min infusion) with vitamins along with Vitamin C is also available for you to choose from for your hydration and wellness needs. $240.

Antioxidant Beauty Blend

Want an effective hydration remedy to get your skin glowing and healthy while sunbathing outside the Coachella Polo Fields? Well, try our new-revamped Antioxidant Beauty Blend that is a 500 ml IV skin rejuvenating therapy (25-30 min. infusion) with Glutathione Antioxidant. $195.
Our full-sized Antioxidant Beauty Blend that is a 1000 ml IV drip (45-60 min infusion) with Glutathione Antioxidant is also available for you to choose from for your hydration and wellness needs. $255.

Muscle Mass Hydration

Want recovery and prevent muscle mass lost when you can’t eat enough protein? Try our new-revamped Muscle Mass Hydration, which includes our Signature Hydration 500 ml IV Therapy (25-30 min. infusion) with analgesic pain remedy and then sip on a whey and casein protein shake with branched-chain amino acids (BCAA) to keep your muscle pumps and decrease soreness from the weekend’s activities. $190.
Our full-sized Muscle Mass Hydration that is a 1000 ml IV drip (45-60 min infusion) with analgesic pain remedy in addition to a supplementary whey and casein protein shake with branched-chain amino acids (BCAA) is also available for you to choose from for your hydration and wellness needs. $250.

Add Ons

Available when purchased with a hydration package listed above!

Indigestion Remedy (Pepcid). $15.
Pain Remedy (Toradol). $20.
Nausea Remedy (Zofran-Sublingual). $30.
Vitamin B-12. $30.
Vitamin C. $30.
Lactated Ringers Upgrade. $30.
Acetyl-L-Carnitine (ALC, Amino Acid). $35.
Alpha Lipoic Acid (ALA, Amino Acid). $35.
Nausea Remedy (Zofran-Intramuscular). $40.
Vitamin B Complex (B-Vitamins). $50.
Multivitamin. $50.
Glutathione Antioxidant. $50.
Extra 500 ml Fluid (Normal Saline). $50.
Extra 500 ml Fluid (Lactated Ringers). $70.
High Dose Vitamin C. $100.

A La Carte Services

Don’t have time for an IV infusion but need a much needed energy boost, pain relief for your headache and muscles, or just queasy from the weekend? Look no further and try our A La Carte Services!

Indigestion Remedy (Pepcid). $15.
Pain Remedy (Toradol). $20.
Nausea Remedy (Zofran-Sublingual). $30.
Vitamin B-12. $30.
Vitamin C. $30.

Group Concierge Services

Why leave the comfort of your own home or hotel? Have us come to you!

We do have special rates for those looking for a Group Concierge Services.

Concierge Fee For VIP Guests: $150
- Prepaid and Pre-booked for Four (5) or More Guests: Waive Your Concierge Fee!
Gratuity: $15%
- Note: There is a 15% gratuity charge for all concierge and off-site services.

Individual Concierge Services

If you are a one-party visitor you can take advantage of our individual concierge services.

Personalized Hydration 1000 ml IV Therapy with vitamins and a blend of nausea, pain, or indigestion remedies (45-60 min) option during our normal business hours from 9:00 am to 6:00 pm. $360.
After Hours Hydration 1000 ml IV Therapy with vitamins and a blend of nausea, pain, or indigestion remedies (45-60 min) option after 6:00 pm and into the wee hours of your night or morning. $450.
Gratuity: $15%
- Note: There is a 15% gratuity charge for all concierge and off-site services.

Pre-booking Non-refundable Deposit

We would need a pre-booking non-refundable deposit for our services to officially schedule our IV Hydration Therapy sessions. All appointments require a booking deposit for in-office and off-site services.

In-office appointments: $99.00.
Concierge Fee For VIP Guests: $150
- Prepaid and Pre-booked for Four (5) or More Guests: Waive Your Concierge Fee!
Birthdays Services: $200
- Prepaid and Pre-booked for Four (5) or More Guests: Waive Your Concierge Fee!
Weddings Services: $400
- Prepaid and Pre-booked for Ten (10) or More Guests: Waive Your Concierge Fee!
All-Star Celebrity Services: $600
- Prepaid and Pre-booked for Ten (10) or More Guests: Waive Your Concierge Fee!

Cancellation and Rescheduling

More Than 48 Hours
- Registration cancellations more than 48 hours from start of a service/appointment will receive a 100% refund, minus a $25 administrative fee per scheduled guests, clients, and customers.
- Cancellations must be made within 48 hours of appointment time to receive a refund.
48 Hours or Less
- No refunds will be issued for cancellations 48 hours or less prior to the service/appointment. However, such guests, clients, and customers may attend a future service/appointment by paying a $35 rescheduling fee.
- Once the service/appointment has begun or been rescheduled, no refunds will be given unless otherwise stated or agreed upon.
Lack of Participation/Emergency Situations
- We reserve the right to cancel or reschedule a service/appointment due to the lack of participation or personnel/workplace emergency situations. Please be advised that notification of canceled or rescheduled service/appointment (s) will be given by phone or email as soon as possible.

Menus

Meanwhile, you can take a look at our Wellness Menus at your own convenience and tell us which in-house or off-site concierge Replenish 360 IV hydration amenities you want to activate. We will gladly inform our staff RNs and medical team who are on duty to provide you with our one-of-a-kind and VIP IV vitamin drip during the weekday and weekend that you are in town for the Coachella, Splash House, and the rest of the Festival Season!

Contact Information

For more information, please contact us by phone, email, or just set up your appointment and session online!

Telephone: (760) 422-3114
Email: [email protected]
Online Registration!

EXPERIENCE RELIEF!!!

GOODBYE

dehydration

fatigue

cold & flu symptoms

headache & migraines

chronic pain

stress and anxiety

insomnia

HELLO

hydration

vibrant energy

immune support

pain relief

muscle rebound

sharper focus

better sleep

About IV Therapy

“Replenishing your mind and body, restoring you to your best self, and improving your health and everyday performance.”

Our R360 motto above is what we always strive for whenever you come into our one-of-kind and relaxing IV Hydration Therapy and Wellness Clinic. We will always welcome you with open arms in certain cases when you may be sniffling and whimpering through a mild cold, the “achy-breaky” flu, and/or other upper respiratory infection (URI) with or without nausea and vomiting; the “runs” from a bug that you unfortunately caught after consumption of contaminated food; had a bit of a discomforting and nagging hangover from the once-in-a-lifetime party or special occasion you gladly experienced the night before; are a very competitive athlete who may need to boost their physical performance and recovery with IV hydration post-intense workout; or you are just very worn out because of the jet-lag feeling from a red-eye flight and you may have not had the chance to drink enough water and ingest enough nutrients throughout your traveling on top of your busy schedule and the hard days work. These are small and minute but prime examples of different types of sometimes unavoidable life occurrences which may not be at all averted entirely, which may probably lead to your mild to moderate dehydration and the sequelae of uncomfortable signs and symptoms stemming from the lack of daily oral water, nutrients, and vitamin intake.

It is, therefore, only merited that our sole mission is to commit ourselves to reviving and helping healthy people recover from these unforeseen instances of mild to moderate dehydration by administering IV hydration fluids, nutrients, vitamins, and amino acids in addition to other stabilizing and wellness services via our professional mobile and brick/mortar IV Hydration Therapy Clinic and Wellness Clinic to replenish your mind and body, restore you to your best self, and improve your health and everyday performance.

We want to be your favorite and most reliable service and facility of choice for your hydration and adjunct supplementary wellness service needs, not only in our state-of-the-art and tranquil IV Hydration Therapy and Wellness Clinic, but also at the comfort of your own home or hotel room when you are sick with a mild infection affecting your daily physical and mental performance; your special occasions and personal life events such as birthdays, weddings, Bar Mitzvahs, and other extraordinary life celebrations; community events and astounding music festivals like the infamous Coachella Festival, Stagecoach Festival, Desert Trip Shows, and other hot entertaining concerts and exceptional celebrations; your local bars, pubs, taverns, night clubs, dance clubs, and other fun venues to prevent the aggravating signs and symptoms of dehydration; and, lastly, immersed in your sporting events at your native gym and maybe even in within an arm’s reach of your practices, tournaments, and competitive sports when you need a little lift with hydration, vitamins, and other nutrients to help you achieve your peak physical and mental performance and recover faster than you could ever have.

IV Hydration Services available in the following Palm Desert area cities:

Palm Desert (92211,92255,92260,92261)
Palm Springs (92262,92263,92264)
West Palm Springs
Cathedral City (92234,92235)
Rancho Mirage (92270)
Indian Wells (92210)
Indio (92201,92202,92203)
Desert Hot Springs (92240,92241)
Idyllwild-Pine Cove (92549)
Coachella (92236)
Bermuda Dunes
La Quinta (92247,92248,92253)
Sun City (92585,92586,92587)
Thousand Palms (92276)

WEST FROM PDRE
Redlands (92373, 92374, 92375)
Morongo Valley (92256)
Cabazon (92230)
Banning (92220)
Beaumont (92223)
Yucaipa (92399)
San Jacinto (92581, 92582, 92583)
Hemet (92543, 92544, 92545, 92546)
Temecula (92589, 92590, 92591, 92592, 92593)
NORTH FROM PDRE
Twentynine Palms (92277, 92278)
Yucca Valley (92284, 92286)
Big Bear Lake (92315)

EAST FROM PDRE
Joshua Tree (92252)
Salton Sea (92275)
Brawley (92227)
El Centro (92243, 92244)
Blythe (92225, 92226)
Calexico (92231, 92232)
SOUTH FROM PDRE
Borrego Springs (92004)
Anza (92539)

References and Other Scholarly Articles:

Disclaimer: The safety and scientific validity of these referenced and independent scholarly studies is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.